Budiatin, Aniek Setiya and Khotib, Junaidi and Hasmono, Didik and Samirah, Samirah (2016) Injektabel Komposit Hydroksiapatit-Gelatin sebagai Sistem Penghantaran Alendronat. Jurnal Farmasi dan Ilmu Kefarmasian Indonesia, 3 (1). p. 5. ISSN 2406-9388

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Abstract

Background:Bisphosphonates, such as alendronate (ALE), have been known to be effective in thetreatment of bone cancer and osteoporosis. However, it has been reported that the systemicadministration of ALE causes a considerable side effect. Thus, the formulation injectable bone substitute(IBS) for local administration of ALE, which functions as drug delivery system (DDS) as well as fillingagent in osteoporosis-induced bone fracture, is needed.Objective:To establish the biodegradable andbiocompatible formulation for ALE in injectable form which supports the drug delivery system and acts asfilling agent in bone fracture.Methods:Hydroxyapatite (HA) was added to the mixture of gelatin andhydroxypropyl methyl cellulose (GEL-HPMC). ALE was added to the mixture and semisolid form wasprepared for granulation. The dried granule, as injectable matrix, was grinded and mixed withappropriate amount of Na2 .Results:Porosity of injectable form was higher than those of granuleform. Injectable semisolid form was produced by adding 0.8 mL Na2 HPO4 HPO4 on each gram of granule with10-12 min setting time. MTT assay showed that matrix was biocompatible showed by more than 100%viability. In vitro dissolution study showed that ALE was slowly released in more than 20 days.Conclusions:The formula of IBS using HA-GEL-HPMC may act as an effective drug delivery system forlocal administration of ALE in bone fracture. Keywords: hydroxyapatite,gelatin, HPMC,alendronat,Na2HPO4, DDS (Drug Delivery System)

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