Yudi Wicaksono and Dwi Setyawan and Siswandono (2017) Formation of Ketoprofen-Malonic Acid Cocrystal by Solvent Evaporation Method. Indonesian Journal of Chemistry, 17 (2).
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Abstract
The purpose of this work was to explore the formation of ketoprofen-malonic acid cocrystal by solvent evaporation method. Early detection of cocrystal formation was conducted by hot stage microscopy and solid-liquid phase diagram. Cocrystal were prepared by solvent evaporation method by using isopropyl alcohol as solvent. Characterization of cocrystal was done by Powder X-Ray Diffractometry (PXRD), Differential Scanning Calorimetry (DSC), Fourier Transform Infrared (FTIR) Spectroscopy and Scanning Electron Microscopy (SEM). The results of hot stage microscopic and solid-liquid phase diagram indicated formation of ketoprofen-malonic acid cocrystal. PXRD and DSC measurements showed stoichiometric ratio of cocrystal ketoprofen-malonic acid (2:1). The ketoprofen-malonic acid cocrystal had melting point at 86.2 °C and unique peaks of PXRD pattern at 2θ of 6.1°, 17.8°, 23.2° and 28.6°. FTIR spectra indicated the formation of cocrystal due to interaction of C=O ketone group of ketoprofen with MA molecule. SEM images show that ketoprofen-malonic acid cocrystal have multi-shaped particles with rough surfaces. Keywords: ketoprofen; cocrystal; hot stage microscopy; solid-liquid phase diagram
| Item Type: | Article | ||||||||
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| Uncontrolled Keywords: | ketoprofen; cocrystal; hot stage microscopy; solid-liquid phase diagram | ||||||||
| Subjects: | R Medicine R Medicine > RS Pharmacy and materia medica R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica R Medicine > RS Pharmacy and materia medica > RS200-201 Pharmaceutical dosage forms |
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| Divisions: | 05. Fakultas Farmasi | ||||||||
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| Depositing User: | Mr M. Fuad Sofyan | ||||||||
| Date Deposited: | 21 Nov 2018 11:02 | ||||||||
| Last Modified: | 13 Dec 2018 09:31 | ||||||||
| URI: | http://repository.unair.ac.id/id/eprint/73330 | ||||||||
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