SINTESIS TURUNAN DIALKILAMINOMETIL PINOSTROBIN (BASA MANNICH) DENGAN MENGGUNAKAN IRADIASI GELOMBANG MIKRO

I GEDE ARI SUMARTHA, 051414153021 (2018) SINTESIS TURUNAN DIALKILAMINOMETIL PINOSTROBIN (BASA MANNICH) DENGAN MENGGUNAKAN IRADIASI GELOMBANG MIKRO. Thesis thesis, Universitas Airlangga.

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Abstract

This research was conducted to synthesize the derivatives of dialkylaminomethylpinostrobin as the target compound by using Mannich reaction to enhance bioactivity of pinostrobin. The synthesis using microwave irradiation was done in one pot reaction. The product was then purified by column chromatography to give purified products, which were analysed using IR, 1HNMR, 13C-NMR and mass spectroscopy to determine their structures, and it was concluded that the obtained compounds were 6-(4-methylpiperazine-1- ylmethyl)pinostrobin in 63,64% yield, 6-(piperidin-1-ilmetil)pinostrobin in 12,14% yield, 6-[(N,N-dibutilamino)metil]pinostrobin in 24,97% yield, 6- (morfolin-1-ilmetil)pinostrobin in 74,30% yield and 6-[(N,N-dietilamino)metil]- pinostrobin in 19,40% yield.

Item Type: Thesis (Thesis)
Additional Information: KKB KK-2 TF. 25-18 Sum s
Uncontrolled Keywords: Mannich reaction, Pinostrobin, Formaldehyde, Microwave Irradiation
Subjects: R Medicine > RM Therapeutics. Pharmacology > Including massage, exercise, occupational therapy, hydrotherapy, phototherapy, radiotherapy, thermotherapy, electrotherapy
Divisions: 05. Fakultas Farmasi
Creators:
CreatorsNIM
I GEDE ARI SUMARTHA, 051414153021UNSPECIFIED
Contributors:
ContributionNameNIDN / NIDK
Thesis advisorHadi Poerwono, Drs., Apt., MSc., PhD.UNSPECIFIED
Thesis advisorAchmad Syahrani, Prof. Dr., MS., Apt.UNSPECIFIED
Depositing User: Tatik Poedjijarti
Date Deposited: 02 Nov 2018 09:34
Last Modified: 02 Nov 2018 09:34
URI: http://repository.unair.ac.id/id/eprint/75249
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