Winantari, Agnes Nuniek and Setyawan, Dwi and Siswandono, Siswandono (2016) Identification of Physical Interaction in Binary Systems of Acyclovir–Succinic Acid. Jurnal Farmasi dan Ilmu Kefarmasian Indonesia, 3 (1). pp. 27-31. ISSN 2406-9388

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Abstract

Acyclovir, a guanosine analogue antiviral drug with low solubility of water. Due to its poorsolubility and permeability, causes low oral bioavailability.Objective:The aim of this research is toinvestigatethe physical interaction in binary systems acyclovir-succinic acid (AS).Methods:Themsystemwas prepared by solvent evaporation method.Results:Thermogram Differential Scanning Calorimetryshowed endothermic peaks at 172.68 o C(ethanol) and 171.84 o C (methanol). The Powder X-RayDiffraction (PXRD) pattern of ASwasdifferent from pure component and physical mixtures. Furthermore,physical characterization showed the binary system of AS have unique crystal habit by polarizationmicroscope.Conclusion:New crystalline phase is formed from the interaction between acyclovir andsuccinic acid by solvent evaporation methodusing ethanol and methanol.Keywords:physical interaction, acyclovir, succinic acid, binary systems

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