Sari, Retno and Suhartanti, Titin and Hendradi, Esti and Soeratri, Widji (2014) CHITOSAN BASED PARTICULATE CARRIER OF DITERPENE LACTON OF SAMBILOTO PREPARED BY IONIC GELATION-SPRAY DRYING :EFFECT OF STIRRING RATE AND NOZZLE DIAMETER. In: ICCPS.
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Abstract
Chitosan, a cationic polysaccharide has many advantages as carrier for drug delivery system such as biocompatible, biodegradable and non toxic.Chitosan has amino group that could be crosslinked with polianion such as tripolyphosphate so that the active ingredient will be entrapped (Agnihotri, 2004, Sinha, 2004). Diterpene lactone fraction of sambiloto (Andrographis paniculata) has antimalarial activity but it has low solubility in water. Entrapped diterpene lactone into chitosan matrix could improve the bioavailability of the active substance. The aim of this research is to investigate the effect of process parameter of chitosan carrier preparation : stirring rate (500 rpm and 1000 rpm) during ionic gelation and nozzle diameter (0.5 mm and 1.0 mm) of spray dryer on physical characteristics of diterpene lactone fraction-chitosan particles. Evaluation of morphology, thermal analysis and drug entrapment were conducted.
| Item Type: | Conference or Workshop Item (Paper) | ||||||||||
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| Subjects: | R Medicine > RS Pharmacy and materia medica R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica R Medicine > RS Pharmacy and materia medica > RS200-201 Pharmaceutical dosage forms |
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| Divisions: | 05. Fakultas Farmasi | ||||||||||
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| Depositing User: | Mr M. Fuad Sofyan | ||||||||||
| Date Deposited: | 22 Nov 2018 13:06 | ||||||||||
| Last Modified: | 22 Nov 2018 13:06 | ||||||||||
| URI: | http://repository.unair.ac.id/id/eprint/75746 | ||||||||||
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