Achmad Firdaus Pamudya Wardhana, NIM011511133104 (2018) KARYA TULIS ILMIAH EFEK EKSTRAK ETANOL DAUN KEMBANG BULAN (Tithonia diversifolia) TERHADAP KADAR SGOT DAN SGPT PADA TIKUS WISTAR (Rattus norvegicus) MODEL DIABETES. Skripsi thesis, Universitas Airlangga.

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Abstract

Background : Kembang Bulan (Tithonia diversifolia) is one of Indonesian traditional medicine that contains saponins, flavonoids, and, tannins and predicted to has a lowering effect on blood-glucose. Diabetes mellitus (DM) is a disease caused by insufficient insulin secretory by the pancreas or ineffective usage of insulin that produced by the body thus cause a hyperglycemia condition. Hyperglycemia can cause an increase in Reactive Oxygen Species which can cause free radicals. Free radicals can cause damage to liver cells. Objective : Determining the effect of ethanol extract of Kembang Bulan (Tithonia diversifolia) on SGOT and SGPT levels in diabetic rats (Rattus novergicus). Method : This was an experiment with post test control group design.. Samples were 40 mice, divided into five different groups (P1, P2, P3, P4 and P5). Each groups were induced by multiple low-dose STZ. P1, P2, and P3 treated with the extract of Tithonia diversifolia, P4 treated with metformin, P5 not treated. Result : On the average results of SGOT levels in the five treatments, using the ANOVA test p value was 0.877 (p> 0.05) which means there were no significant differences. Furthermore, on the average results of SGPT levels in all five treatments, using the ANOVA test p value was 0.822 (p> 0.05) which means there were no significant differences. But from all results obtained P4 (given metformin) with the results closest to normal levels (SGOT: 197.5 ± 37.25; SGPT: 90.33 ± 29.36). From the treatment given Tithonia diversifolia extract obtained P1 (with a dose of 50 mg / 200gr BB) with the results closest to normal levels compared to P2 and P3. Conclussion : The extract of kembang bulan (Tithonia diversifolia) had slightly more lowering effect towards the SGOT and SGPT compared to metformin. Keywords : Diabetes mellitus, Tithonia diversifolia, streptozotocin induced, rat, Transaminase enzyme.

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