NIKHITA ULIANA RAMADAN, 051411133058 (2018) BIOAVAILABILITAS QUERCETIN SETELAH PEMBERIAN ORAL KOKRISTAL QUERCETIN – ASAM MALONAT PADA KELINCI. Skripsi thesis, Universitas Airlangga.

Preview	Text (Abstrak) FF.FK. 15-18 Ram b Abstrak.pdf Download (367kB) | Preview
	Text (Fulltext) FF.FK. 15-18 Ram b.pdf Restricted to Registered users only until 17 December 2021. Download (1MB) | Request a copy

Abstract

Quercetin is a class 2 candidate of the Biopharmaceutics Classification System (BCS), meaning it has a high cellular permeability and low solubility. Therefore, a modification in the formulation of quercetin is needed to increase its bioavailability. This research aims to modify the formulation of quercetin with co-crystalization by adding malonic acid as coformer in order to enhance quercetin’s solubility. The plasma concentration of quercetin was measured with high performance liquid chromatography (HPLC) method. The parameters of bioavailability measured were Tmax, Cmax, and AUC0-480mnt. The results obtained were the average values of these pharmacokinetic parameters. The average Tmax of195 ±174.93 minutes, the average Cmax of 0,56 ± 0,11μg/mL, and the average AUC0-480 of 435.62 ± 137.71 μg.minute/mL were obtained from the single quercetin compound. After the addition of the coformer malonic acid, the average values altered to the average Tmax of 167.50 ± 172.97 minutes, the average Cmax of 0.71 ± 0.38 μg/mL, and the average AUC0-480 of 415.65± 159.01μg.minute/mL. Therefore, it can be concluded that the co-crystal quercetin - malonic acid does not increase the bioavailability of quercetin significantly compared to its single compound according to the average values of Tmax, Cmax, and AUC0-480.

Actions (login required)

View Item