SARI, PUTRI AUDINA, 051411133055 (2018) STUDI PENGGUNAAN CEFAZOLIN PADA PASIEN FRAKTUR TERBUKA GRADE I (Penelitian dilakukan pada kasus orthopedi di Unit Rekam Medis Rumah Sakit Universitas Airlangga Surabaya). Skripsi thesis, Universitas Airlangga.

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Abstract

BACKGROUND. Open fracture infection cases 70% were caused by Gram positive microorganism such as Staphylococcus aureus and Staphylococcus epidermidis. Cefazolin have several benefit such as more active for Gram positive microorganism and due to their high lipofilicity cefazolin has excellent distribution profile in bone. OBJECTIVES. The aimed of this study was to analyze utilization pattern, dosage, frequency, timing of administration, and duration usage of cefazolin. METHODS. The observasional and retrospective method with time limited sampling from January 2nd, 2014 until December 31st, 2017 and descriptive analysis was conducted in this study (N=25). RESULT AND CONCLUTION. The result showed that were 25 patient with open fracture grade I used cefazolin (1x2g) iv as prophylaxis and cefazolin (3x1g) iv used as switch. Two pattern of switch 43% used cefazolin (1x2g) iv and followed by used cefazolin (3x1g) iv. Three Pattern of switch majority (38%) used cefazolin (1x2g) iv followed by used cefazolin (3x1g) iv and when patient discharge the hospital received cefadroxil (2x100mg) po. Four pattern of switch majority (86%) used cefazolin (3x1g) iv followed by using cefazolin (1x2g) iv and then cefazolin (3x1g) and cefadroxil (2x500mg) po when discharge the hospital. Timing of administration prophylactic antibiotic majority 28% received 20 minutes before incision. The duration usage of cefazolin commonly 44% given 2 days. Based on the description, pattern usage of cefazolin including dosage, frequency, timing of administration, and duration usage in open fracture grade I patient at KSM Orthopaedic Universitas Airlangga Hospital has been appropriate with guidelines and other references recommendation.

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