VENNA MAYDA PRATIWI, 051411131084 (2018) STUDI PENGGUNAAN ANTIHIPERTENSI PADA PASIEN DIABETES NEFROPATI (Penelitian di Instalasi Rawat Jalan Ilmu Penyakit Dalam Rumah Sakit Universitas Airlangga Surabaya). Skripsi thesis, Universitas Airlangga.

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Abstract

Background : Nephropathic diabetes (ND) is a common complication of diabetesmellitus. Hypertension can increase the progressivity of nephropathy. Antihypertensif therapy is aimed to reduce the progression of the nephropathy disease and preventing more complications. Aim : the aim of this study is to analyze the utilization of antihypertensive drugsin nephropathic diabetes patients. Methods : It was an observational study with retrospective data collection basedon patients‟ medical records in Outpatients Instalation in RSUA Surabaya from January 1, 2018-March 31, 2018. Results : There were 46 patients who met the inclusion criteria. Based on GFRscore, the most common classification of renal impairment in patients with diabetes in this study was on stage 4 (30.43%). The most common complications were hypertension (52.17%) and hiperlipidemia (21.74%). The drugs that often used were ARB (27.71%), CCB 27.07%, β-blockers 18.79%, diuretics loop (12.42%), ACE-I (7.96%), and potassium-sparing diuretics (6.05%). In this study, single antihypertensive use was 30.43%, two combinations antihypertensives were 31.84%, combinations three were 25.33%, combinations four were 11.57%, and combinations five were 1.44%. Drug related problem of potential drug interaction is candesartan & spironolacton 2.90%, ACE-I & ARB 2.17%. The average of blood pressure measurement that achieved therapy goal (<140/90mmHg) is 30.2%.

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