SANINAH CANDRAWATI RULIFF, 051411131091 (2018) STUDI PENGGUNAAN PROTON PUMP INHIBITOR DAN H-2 RECEPTOR ANTAGONIST PADA PASIEN BEDAH (Studi dilaksanakan di Instalasi Rawat Inap Rumah Sakit Universitas Airlangga Surabaya). Skripsi thesis, Universitas Airlangga.

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Abstract

Background: Postoperative complications can be due to several factors including anesthesia, surgery and patients. Most anesthetic techniques lead to a decrease in the physiological protection mechanisms that prevent the regurgitation and aspiration of gastric content into the respiratory tract, allowing respiratory tracts and organs to be exposed to acidic gastric content. Post surgery patients can also occur complications of Stress-related Mucosal Disease (SRMD). Prevention of aspiration and SRMD in surgical patients can be prevented by fasting before surgery to reduce the volume of gastric contents, or by prophylaxis to reduce the pH of the contents of the stomach. Objective: The aims of this study were to identify the profile of PPI and H2RA including it’s type, dosage, route, frequency of administration, duration, time of drug use and to identify potential drug interaction problems occurred during administration of PPI or H2RA in surgical patients at Airlangga University Hospital Surabaya. Method: This study was retrospective conducted from November 1st 2017 to January 31st 2018. Inclusion criteria were all adult patients undergoing surgery with and without obtaining PPI or H2RA therapy at the Inpatient Installation. Result: Total samples obtained during observation were 265 patients. The results demonstrated that surgical patients mostly received drug therapy, in 216 patients (81.5%). Dataanalysis was performed on 216 patients who received drug therapy. The use of drug therapy classes dominated by the H2RA (Ranitidine) than the PPI (Omeprazole). A single dose ranitidine 50 mg intravenous were administered 30 – 60 minutes before surgery or induction of anesthesia. In postoperative therapy, patients received ranitidine 2x50 mg intravenous route with a duration of 1 – 5 days, and there was a change of therapy in 5 patients, that is intravenous ranitidine to ranitidine 2x150 mg orally or omeprazole 2x40 mg intravenous. This study identified potential drug interactions occured in patients as a minor drug interaction, which is not significant to the patient's clinical condition.

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