MAHFIRA LEILY SYLRAINI, 051411131138 (2018) PENGARUH KADAR DIETILFTALAT TERHADAP KARAKTERISTIK FISIK DAN EFISIENSI PENJEBAKAN Lactobacillus casei FNCC 0090 DALAM MIKROPARTIKEL (Menggunakan Matriks Kopolimer Asam Metakrilat Tipe L). Skripsi thesis, Universitas Airlangga.

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Abstract

Lactobacillus casei is a probiotic that provide health benefit, plays a role in the immune process, and the natural protection of the disease. Drug delivery system such as microparticle is needed to protect Lactobacillus casei from acid condition (gastric) but can release it in alkaline condition (intestine). Methacrylic acid copolymer L-type is used as matrix and combined with diethyl phthalate as plasticizer. The aim of this research is to know the effect of diethyl phthalate concentration (10%, 20%, 30% by weight of methacrylic acid copolymer L-type) to physical characteristics and encapsulation efficiency of Lactobacillus casei FNCC 0090 in microparticle with methacrylic acid copolymer L-type as matrix. Microparticle is formed by spray dry method. The microparticle contain diethyl phthalate 10% by the weight of methacrylic acid copolymer L-type shows optimal morphological results (spherical form, no basin, and has a smooth/non-porous microparticle’s surface) and also has the smallest moisture content. Particle size is increase with the increasing of diethyl phthalate level. The result of FTIR spectra examination shows a decrease of wavelength number of hydroxyl (–OH) group due to the formation of hydrogen bond on microparticles. Optimum encapsulation efficiency of Lactobacillus casei FNCC 0090 is found in the formula with the addition of diethyl phthalate 10% by methacrylic acid copolymer L-type with a percentage of 91.43%.

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