MUHAMMAD AVIV ADDIN, 051411131033 (2018) PENGARUH KADAR HPMC K4M TERHADAP KARAKTERISTIK FISIK DAN EFISIENSI PENJEBAKAN Lactobacillus casei FNCC 0090 DALAM MIKROPARTIKEL DENGAN MATRIKS KOPOLIMER ASAM METAKRILAT TIPE L (Metode spray drying). Skripsi thesis, Universitas Airlangga.
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Abstract
Microencapsulation is the process of encapsulating solid, liquid, or gaseous material with a polymer aimed to protect the active ingredients from degradation due to pH also to obtain a pulsatile release. One of the active ingredients that requires a microencapsulation process is a probiotic, which lacks the ability to survive in an acidic environment such as the gut, while intended for intestinal release. This study was aimed to determine the effect of HPMC K4M concentration (0.2%, 0.3%, and 0.4%) in combination of Ltype metacrylic acid copolymers to physical characteristics and encapsulation efficiency of Lactobacillus casei in microparticle, made by spray drying method. The test results of probiotic microparticle physical characteristics could be seen in each formula. The Increasing of HPMC K4M rate in 0,2% to 0,3% does not have influence on particle size, however in concentration of 0,3% to 0,4% may cause a decrease on particle size. The observation of Scanning Electron Microscopy (SEM) shows that microparticles produced have surfaces with many cavity with a shape that tends to be non-spherical. There is no effect of increased HPMC K4M concentration on moisture content of microparticle and still yields high moisture content. The results also show that Lactobacilus casei encapsulation efficiency increases in microparticle by being added HPMC K4M in polimer combination compared to without combination, nevertheless the increased concentration of HPMC K4M has no effect in Lactobacilus Casei encapsulation efficiency in microparticle.
| Item Type: | Thesis (Skripsi) | |||||||||
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| Additional Information: | KKB KK-2 FF.F. 35-18 Add p | |||||||||
| Uncontrolled Keywords: | Microencapsulation, Probiotic, HPMC K4M, Methacrylic acid copolymer L type, Lactobacillus casei, Spray drying, Physical characteristic, Encapsulation efficiency | |||||||||
| Subjects: | R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica | |||||||||
| Divisions: | 05. Fakultas Farmasi > Farmastika | |||||||||
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| Depositing User: | Tatik Poedjijarti | |||||||||
| Date Deposited: | 28 Dec 2018 02:45 | |||||||||
| Last Modified: | 28 Dec 2018 02:45 | |||||||||
| URI: | http://repository.unair.ac.id/id/eprint/77277 | |||||||||
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