MUHAMMAD FEBRYAN ABIYYU RIFANSA, 061411131063 (2018) EFFECT OF Polygonum minus LEAVES EXTRACT ON THE HISTOPATHOLOGICAL CHANGES OF LIVER’S MICE (Mus musculus) INDUCED BY CADMIUM CHLORIDE. Skripsi thesis, Universitas Airlangga.

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Abstract

The aim of this study was to examined the protective effect of Polygonum minus leaf extract on histopathological changes of the liver induced by Cadmium chloride in mice (Mus musculus). Thirty male mice were divided into five groups, six mice each and administered through oral gavage with different treatments for 21 days. The treatments were C– (CMC Na 0.5% solution + aquadest), C+ (CMC Na 0.5% solution + 12 mg/kg bw Cadmium chloride), T1, T2, and T3 (200, 400, and 800 mg/kg bw Polygonum minus leaf extract respectively + 12 mg/kg bw Cadmium chloride). After treatments, histopathological evaluation was done to calculate the percentage of the lesion using Arsad scoring method. The data was analyzed by Kruskal Wallis and Mann-Whitney Test. The research showed significant different decrease (p < 0.05) among the treatment groups. The conclusion of this research is Polygonum minus leaf extract can protect mice liver from destructive effect of Cadmium chloride, and the best dose was 400 mg/kg bw.

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