Esti Hendradi and Tutiek Purwanti and Karina Wahyu Irawati (2014) Characterization of Dosage Form and Penetration Diclofenac Sodium with Microemulsion System in HPMC 4000 Gel Base (Microemulsion W/O with rasio use of surfactant Span 80 – Tween 80 : Cosurfactan Ethanol 96% = 6:1). In: Proceeding the 1st International Conference on Pharmaceutics & Pharmaceutical Sciences. Faculty of Pharmacy Universitas Airlangga, Surabaya, pp. 95-98. ISBN 978-602-72333-0-0

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Abstract

Diclofenac is NSAID that has actvated as antinflammaton, analgesic and antpyretcs (Schuelert, 2011). Diclofenac sodium has partton coefcient of 13.4 (Hasan et.al.2005) which means diclofenac sodium has a partton in oil a higher amount than in the water. By usage two phases to diclofenac sodium like emulsion, diclofenac sodium can dispersed in the inital phase oil and water. But emulsion has thermodynamically unstable (Allen, 1997). So that, needed a system more stable for dispersion of diclofenac sodium to produce a more effectve preparaton, namely microemulsion system. The characteristcs of microemulsion are stable in thermodynamics, transparent, low viscosity, and have high solubilisasion so that it can increase bioavailability drugs in the body (Santos et al., 2008). To overcome the low viscosity of microemulsion by adding hydroxi prophyl methyl cellulose (HPMC). The aim of this study was to observe characterizaton dosage form and penetraton of diclofenac sodium in microemulsion system which contained rato surfactant Span 80-Tween 80 an cosurfactant ethanol= 6:1

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