Athiyah, Umi and Suprapti, Budi and Yulistiani, Yulistiani and Zulkarnain, Bambang Subakti (2002) Profil Disolusi Berbagai macam Tablet Fenilbutazon yang Beredar di Pasaran. Jurnal Penelitian Medika Eksakta, 3 (2). pp. 130-136. ISSN 1411 – 6626

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Abstract

The objective of this study was to identify the dissolution profile of various phenylbutazone tablets in market using content homogeneity and dissolution and dissolution efficiency as a parameters. Four phenylbutazone tablets labeled as A, B, C and D were used in this study phenvlbutazone study. The homogeneity TABLET test was carried out using methanol as a medium. A basket method of USP XXIII using buffer phosphate ph 7.5 was applied as a dissoiution test procedure. and D met the standard requirement The cement homogeneity test resulted in that A. B whereas C had the content homogeneity exceed that requirement. Furthermore, the dissolution test results showed that test result showed that A and D did not meet the standard requirement of USP XXIII In contrast, B and C met that standard requirement. Also, 60 minutes dissolunon efficiency (ED.o) showed there were significantly different among them (ANOVA and Tuckey HSD c = 0.05). in conclusion, the content homogeneity and dissolution efficiency of four tablets showed that there were different in quality. The results of this study should be informed to the relevant institution and pharmaceuncal industries to improve the product quality.

Item Type:	Article
Uncontrolled Keywords:	phenylbutazone , dissolution profile
Subjects:	R Medicine R Medicine > RS Pharmacy and materia medica R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica R Medicine > RS Pharmacy and materia medica > RS200-201 Pharmaceutical dosage forms
Creators:	Creators NIM Athiyah, Umi UNSPECIFIED Suprapti, Budi UNSPECIFIED Yulistiani, Yulistiani UNSPECIFIED Zulkarnain, Bambang Subakti UNSPECIFIED
Depositing User:	Mr M. Fuad Sofyan
Date Deposited:	05 Jan 2019 14:51
Last Modified:	27 Apr 2022 07:42
URI:	http://repository.unair.ac.id/id/eprint/77658
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