Purwanto, Bambang Tri (2013) Modifikasi struktur N-fenilurea menjadi senyawa baru N-benzoilfenilurea dan 4-fluorobenzoilfenilurea serta uji aktivitasnya sebagai penekan susunan syaraf pusat (Author). Majalah Berkala Ilmiah Kimia Farmasi, Departemen Kimia Farmasi FF Unair, 2 (1). pp. 28-32. ISSN 2302-8270

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Abstract

Modification of the structure of to the N-benzoylphenylurea and 4-fluorobenzoylphenilurea as the new compound has been done. The Scholten-Baumann method was used/or the reaction between N-phenylurea and benzoyl Chloride and 4-fluorobenzoyl chloride. The CNS depressant activity test was done for the N­benzoy/phenylura and 4-fluorobenzpylphenylurea compound by Barbituric Sleeping Time (BST) method. The yield of the N-benzoylphenylurea was 86% and the 4-jluorobenzoylphenylurea was 71% • had a white crystal and gave one spot in Thin Layer Chromatography with two different eluent. The compounds melting point was different from the Nsphenylurea and showed greater. The structure identification from the new compounds was analysed by IR, 1 HNMR and MS, the result showed that the new compounds was N­ benzoy!phenylurea and 4-.fluorobenzoylphenylurea. The CNS depressant activity test from N-benzoylphenylurea and 4-.fluorobenzoy/phenylurea had a greater activity if compare with the standard compound bromisoval.

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