RAUDATUL PATIMAH, 051614153013 (2018) PENGARUH KADAR HPMC 606 TERHADAP KARAKTERISTIK SEDIAAN DAN PENETRASI COENZYME Q10 DALAM SISTEM NANOSTRUCTURED LIPID CARRIER (NLC) PADA PATCH TIPE MEMBRAN. Thesis thesis, Universitas Airlangga.

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Abstract

Coenzyme Q10 has functions of providing and preventing the skin. Reactive oxygen species can be restrained and the peroxidation form of lipid would be slowed and protected by Coenzyme Q10. However, Coenzyme Q10 has limited due to solubility in water is very low (4 ng/ml), causing low bioavailability and permeability of the oral administration. This research was investigate the effect of concentration of HPMC 10%, 15% and 20% on the characteristics and penetration of Coenzyme Q10 transdermal patch. Coenzyme Q10 NLC system with different lipid ratio 70:30 (cetyl palmitate and alpha tocopheryl acetate) used as drug reservoir dan hydroxypropyl methylcellulose 606 (HPMC 606) as rate controlling membrane. NLC Coenzyme Q10 as drug reservoir were prepared using high shear homogenization method. Transdermal patch was using membrane type with HPMC 606 as rate controlling membrane. This research was investigate the effect of concentration of HPMC 606 (F1=10% ; F2=15% ; and F3=20%) on the characteristics Coenzyme Q10 transdermal patches. The prepared transdermal patches were evaluated for thickness, weight variation, moisture content, drug content and drug homogenity. All independent variables had no significant effect on the dependent variables (p-values > 0.05) using one way ANOVA, except the weight and moisture content patches. Coenyme Q10 patches in F1 has better characteristics than other formulas. Coenzyme Q10 levels which penetration the most in F1 at 6 hour with 83,53 ± 1,34 %, flux 15,714 ± 0,257 %/hour and lag time 0,523 ± 0,029 hour. Variation concentration of HPMC 606 used in the transdermal patches of Coenzyme Q10 give effect to the characteristic and penetration in vivo.

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