Diana Murtiati Kusuma, NIM011318246301 (2018) PERBANDINGAN KOMPOSISI SEL LEMAK COKLAT DAN SEL LEMAK PUTIH PADA PENDERITA OBESITAS DAN NON-OBESITAS DI RSUD DR. SOETOMO SURABAYA. Thesis thesis, Universitas Airlangga.

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Abstract

Background: Obesity can cause an increased risk of serious illnesses and premature death. The incidence of obesity is become widely spread, associated with ineffective therapy. Several studies have shown that brown fat cells in the body are useful to remove large amounts of chemical energy. Increasing the amount of brown fat is an effective way to burn calories. The amount of brown fat cells in adult humans is being questioned recently and there is no exact data on the ratio between brown fat cells and white fat cells in the adult human body, especially in the obese. The purpose of this study is to prove that the amount of brown fat cells in obese patients is less compared to that in non-obeseones. Methods: This study is an observational study, in which the dependent variable is Cell Marker Expression CD137 and Hematoxylin and Eosin (H&E), examined by mmunohistochemistry. This variable is evaluated based on the percentage of its amount from the total number of cellsfound in pathology examination. If CD137 ≥ 72%, then this ndicates that brown fat cells are dominant. Samples are taken from the supraclavicular area of 12 adult patients, both obese and non-obese. Result : Observation of the study does not prove that the amount of brown fat tissue in obese patients is less than that of non-obese. The proportion of brown fat tissue cannot be compared to white fat tissue in obese and non-obese people. Conclussion: In this study, Brown fat tissue was not found in obese and non-obese patients, with CD137 and H&E staining, which was seen only in white fat cells. The proportion of bown fat tissue cannot be compared to white fat tissue in obese and non-obese patients.

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