WINIE FARISAH, 051411133010 (2019) PENENTUAN KADAR GULA DARAH SETELAH PEMBERIAN SERBUK PORANG (Amorphophallus oncophyllus) DAN SERBUK KONJAK (Amorphophallus konjac) TERSTANDARDISASI GLUKOMANAN PADA TIKUS PUTIH (Rattus norvegicus). Skripsi thesis, Universitas Airlangga.

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Abstract

The aim of this research is to know the hypoglycemic effectsof the porangpowder (Amorphophallus oncophyllus) and Konjac powder (Amorphophallus konjac), both standardizedin their glucomannan content. The glucomannan levelsinporang and konjac powder were 52,33 ± 0,74% (w/w)and 61,24 ± 0,61% (w/w), respectively. Glucomannan contained in porangtuber functions as water soluble hemicellulose fiber whichhas low calories. The experimental animals used in this study were white rats (Rattus norvegicus) induced with alloxan monohydrate. Blood samples were taken from the tail end of male white rat (Rattus norvegicus) aged 2-2,5 months with the weight of 100-250 grams. The treatment group was divided into 8 groups, which included negative control group (CMC Na 0.3%), positive control group (glibenclamide 0,455 mg / kg white rat), porangpowderdosage group I; II; III (with the dosage of 59,5 mg / kg white rat; 115,5 mg / kg white rat; 175 mg / g white rat BB calculated as glucomanan, respectively), and konjac powder dosage group I; II; III (with the dosage of 59,5 mg / kg white rat, dose 115,5 mg / kg white rat, dose 175 mg / kg white rat calculated as glucomanan, respectively). The treatment was done every day for 21 days with a measurement of blood sugar levels performed every 3 days and daily body weight performed every day. Prior to treatment, white rats had been subjected to adaptation for one week and abstained from food for 18 hours. The data obtained were analyzed using One Way ANOVA with significance linier: by (p<0,01 ; p<0,05). The results obtained showed that the konjac powder dosage group III (175 mg / kg body weight / day calculated as glucomannan) is the most effective dose to lower blood sugar levels.

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