PENGARUH TERAPI ADJUVAN DEKSAMETASON SUBKONJUNGTIVA TERHADAP KADAR INTERLEUKIN-6 (IL-6) DAN TRANSFORMING GROWTH FACTOR BETA 2 (TGF-β2), DI CAIRAN VITREUS PADA PROLIFERATIVE VITREORETINOPATHY GRADE B-C (Studi Eksperimental pada Pasien Rhegmatogenous Retinal detachment di RSUD Dr. Soetomo)

Tri Subekti, NIM011428016304 (2019) PENGARUH TERAPI ADJUVAN DEKSAMETASON SUBKONJUNGTIVA TERHADAP KADAR INTERLEUKIN-6 (IL-6) DAN TRANSFORMING GROWTH FACTOR BETA 2 (TGF-β2), DI CAIRAN VITREUS PADA PROLIFERATIVE VITREORETINOPATHY GRADE B-C (Studi Eksperimental pada Pasien Rhegmatogenous Retinal detachment di RSUD Dr. Soetomo). Thesis thesis, Universitas Airlangga.

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Abstract

Objective: To evaluate IL-6 and TGF-β2 levels in the vitreous of PVR grade B-C with rhegmatogenous retinal detachment patients that were given subconjunctival dexamethasone adjuvant therapy compared to the group who received no adjuvant therapy at RSUD Dr. Soetomo Surabaya. Material and Methods: In this experimental study, 36 patients were enrolled and randomly assigned to two groups: adjuvant subconjunctival dexamethasone 10 mg (treatment group: 20 patients) and no adjuvant therapy (control group: 16 patients). Group A (20 patients) was given adjuvant therapy with subconjunctival dexamethasone 10 mg as treatment group, and Group B (16 patients) was not given adjuvant therapy as control group. Dexamethasone 10 mg adjuvant therapy was given 5-6 hours before vitrectomy and vitreous samples were collected by pars plana primary vitrectomy. All vitreous samples were immediately frozen at - 80º C. Vitreous levels of IL-6 and TGF-β2 were measured using Human sandwich ELISA. The outcomes were analyzed using the Mann-Whitney test. Results: The mean intravitreal IL-6 level was 334.23 pg/ml in the treatment group and the mean intravitreal IL-6 level in the control group was 157.52 pg/ml. The mean intravitreal TGF-β2 level was 223.93 pg/ml in the treatment group and the mean intravitreal TGF-β2 level in the control group was 151.85 pg/ml. Conclusion: There was no significant differences between the reduction of IL-6 and TGF-β2 levels in the treatment group and the control group.

Item Type: Thesis (Thesis)
Additional Information: KKA KK PPDS.IKM. 05-19 Sub p
Uncontrolled Keywords: RRD, Subconjunctival injection, Dexamethasone, PVR, IL-6, TGF-β2, Adjuvant therapy
Subjects: R Medicine > RE Ophthalmology
Divisions: 01. Fakultas Kedokteran > Ilmu Penyakit Mata
Creators:
CreatorsNIM
Tri Subekti, NIM011428016304NIM011428016304
Contributors:
ContributionNameNIDN / NIDK
Thesis advisorEvelyn Komaratih, Dr., dr., SpM(K)UNSPECIFIED
Thesis advisorSauli Ari Widjaja, dr., SpM(K)UNSPECIFIED
Depositing User: Tatik Poedjijarti
Date Deposited: 21 Jun 2019 08:08
Last Modified: 21 Jun 2019 08:08
URI: http://repository.unair.ac.id/id/eprint/83472
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