RAHAYU CARLIS SAVITRI, 061511535041 (2019) UJI DAYA HAMBAT EKSTRAK METANOL DAUN SUKUN (Artocarpus altilis) TERHADAP PERTUMBUHAN JAMUR Aspergillus fumigatus SECARA In Vitro. Skripsi thesis, Universitas Airlangga.

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Abstract

This study aims to determine the antifungal activity of breadfruit leaves (Artocarpus altilis) methanol extract on Aspergillus fumigatus growth. Aspergillus fumigatus is a fungus that cause the range of pathological condition with invasive pulmonary aspergillosis. Antifungal activity was tested on agar well method for 2 days at room temperature. The results of the inhibition zone data was analyzed using ANOVA (Analysis of Variance) test and followed by Duncan test (p <0.05). The result of inhibition zone from negative control (K-) used DMSO was 0,00a + 0,00 and positive control (K+) using itraconazole 2 μg/ml was 10,32c + 1,62. The result of concentration 1 (P1) using methanol extract of breadfruit leaves 20% was 5,62b + 2,54, concentration 2 (P2) using methanol extract of breadfruit leaves 30% was 6,02b + 1,25, concentration 3 (P3) using methanol extract of breadfruit leaves 40% was 6,67b + 1,21, and concentration 4 (P4) using methanol extract of breadfruit leaves 50% was 4,00b + 2,57. This result showed that methanol extract of breadfruit leaves (Artocarpus altilis) have antifungal activity against Aspergillus fumigatus growth with Minimal Inhibitory Concentration (MIC) 20%.

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