Martianus Perangin Angin and Junaidi Khotib, NIDN. 0022107001 and Wardah R. Islamiyah (2018) The Effect of Phenytoin Loading Dose to Hepatic Enzyme in Epilepsy Patients. Dama International Journal of Researchers, 3 (7). pp. 31-36. ISSN 2343-6743

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Abstract

Epilepsy was defined as neurologic abnormality that was characterized with tendency to cause consistent epileptic seizure and neurobiologist, cognitive, psychologist, and social consequences. According to WHO, it was proximately about 50 million people with epilepsy worldwide. Single use of antiepileptic drug (AED) became first choice in starting epilepsy treatment, because most of patients was successfully controlled by first or second single therapy of AED. Phenytoin mostly was used for focal and generalized seizure type and as second line for mixed seizure type (myoclonic and tonic-clonic). Beside its good effectiveness in controlling seizure, phenytoin also caused significant adverse effects. Such as, phenytoin could cause hepatotoxicity with a couple of days until eight weeks onset, which is characterized by elevation of aspartate aminotransferase (AST).with level range of 2-100 times from normal baseline and also elevation of alanine aminotransferase (ALT). Keywords: Epilepsy, Antiepileptic, Phenytoin, Adverse effects.

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