Retno Pudji Rahayu and Prihartini Widiyanti (2017) SAP3 Gene Expression as Diagnostic Marker of Oral Candidiasis In HIV/AIDS Patients. Engineering and Technology International Journal of Medical and Health Sciences, 10 (1). pp. 156-161. ISSN ISSN 1309-100X

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Abstract

HIV/AIDS cases growth progressively. Oral Candidiasis frequently found in the tract of pathogenesis HIV infection, these condition due to immunocompromised condition among HIV/AIDS patient and one higher complications insidence in oral. Until now, type of cell and receptor of oral mucosa as particularly target of HIV has not been well understood. Secretory Aspartyl Proteinase (SAP) is hydrolytic enzyme secreted by C. albicans which might destruct protein in the site of infection. This enzyme coding by SAP gene and contribute to C. albicans virulency. The aim of this research is to found the expression of SAP3 as the predictor of HIV severity. 30 HIV patients divided into two groups, one group with ARV therapeutic indication (15 patients) and the other group without ARV therapeutic indication. The cotton swab has been done in buccal mucous and dorsum of tongue. The detection would be done by PCR. The result is showed in non-ARV, revealed the presence of SAP3 gene in all samples, but SAP3 gene was not found in all HIV/AIDS samples with ARV. SAP3 could be used as indicator of HIV/AIDS severity, since it was an oral infecton marker related with the degree of host immunodeficiency and C. albicans virulence level.

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