Dwi Rahmawati and Retno Indrawati and Ernie Maduratna Setiawatie and Anita Yuliati and Taufan Bramantoro, 020213089 (2017) Osteogenic Ability of Combined Hematopoetic Stem Cell, Hydroxyapatite Graft and Platelet Rich Fibrin on Rats (Rattus Novergicus). Journal of Krishna Institute of Medical Sciences University., 6 (4). pp. 88-95. ISSN 2231-4261

	Text (ARTICLE) JKIMSU, Vol. 6, No. 4, October-December 2017 Page 88-95.pdf Download (189kB)
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Abstract

Background: In Indonesia, the incidence rate of tooth extraction as the main form of dental treatment reached as high as 79.6% in 2014. Teeth extraction leads to periodontal tissue defect whose treatment, incorporating the use of graft material Hydroxyapatite (HA) and Platelet Rich Fibrin (PRF) with stem cells, has become increasingly widespread. The stem cell potentially put to therapeutic use is the Hematopoetic Stem Cell (HSC). Aim and Objectives: to examine the effect of hematopoetic stem cell addition to HA graft and PRF post-tooth extraction on the number of osteoblasts and amount of Osteoprotegerin (OPG) in periodontal defect treatment. Material and Methods: This study constituted laboratory-based experimental research with a post test-only control group. Twenty four rats (Rattus novergicus) represented the animal study model in this research.

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