Imam Susilo, NIDN. 0010086503 (2012) Ekspresi protein er (estrogen receptor) pada kanker payudara derajat keganasan baik, sedang dan buruk (protein expression er (estrogen receptor) in breast cancer degree of malignancy low, moderate, severe). Jurnal Ners, 7 (1). pp. 91-96. ISSN 1858-2598

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Abstract

Introduction: Mammary carcinoma is the most common malignancy and main mortality cause in woman. Hormonal status (ER and PR expression) was long used as patient suitability for hormonal therapy. But lately there are many patients with ER and PR negative. Pada kesempatan ini, peneliti ingin membuktikan relevansi ekspresi protein ER (estrogen receptor) dengan derajat keganasan histopatologik kanker duktal invasif payudara dan prognosisnya antara kanker payudara dengan ekspresi protein ER positif dan negatif. Method: In this retrospective and cross sectional analitical study, we retrieved data about hormonal status (ER expression) and histopathological grading of infiltrating ductal carcinoma patients. This study consisted of 201 patients with mammary carcinoma who referred to medical records Department Pathology Anatomic of Faculty Medicine Airlangga University / Dr. Soetomo General Hospital Surabaya on 1 January 2010-31 December 2010 and their medical record suitable with inclusion criterias. The data was catagorized in several groups based on ER expression result. Results: Most of the sample was in 41-50 years age group (37,31%), and 54,7% of them were in poor expression. The relationship of estrogen receptor (ER) with the degree of histopathology infiltrating ductal carcinoma patients, obtained p-value = 0.001 (p <0.5) and the 2x2 table is only moderate and severe degrees compared with the results of ER expression results obtained p = 0.001 (p <0.5) and Odds ratio of 0.362 (CI: 0194-0675). Discussion: This study found significant correlation between ER expression with histopathological grading of infiltrating ductal carcinoma patients.

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