Reny I'tishom, - and Rochmah Kurnijasanti, - (2009) Utilization of Extract Phaleria (Phaleria macrocarpa) as a Precaution Against Carbon Tetrachloride Induced Hepatotoxicity in Mice. Folia Medica Indonesiana, 45 (4). pp. 249-252. ISSN 0303-7932

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Abstract

The hepatoprotective activity of extract of mahkota dewa fruit's (Phaleria macrocarpa) was investigated against Carbon Tetracloride (CC14) induced hepatic damage. Carbon Tetracloride at a dose of0,3 mllkg body weight produced liver damage in mice as manifested by the rise in serum level of Glutamate Pyruvate Transaminase (GPT) and Glutamate Oxaloacetat Transaminase (GOT) to 31.4286 ± 2.4398 and 87.1429 ± 2.4398 respectively, compared to respective control values of23.0000 ± 1.7889 and 39.0000 ± 3.6968. Pretreatment ofmice with mahkota dewafruit's extract at concentration of2.5; 5; 10 mglkg body weigth significantly prevent (p< 0.001) Carbon Tetracloride induced rise in serum enzymes and the estimated values ofGPTwas 27.2857 ± 1.9760; 22.8750 ± 2.1002 and 22.1667 ± 1.3239 respectively, and GOT was 53.0000 ± 8.6410 ; 45.1429 ± 3.4365 and 40.6667 ± 7.1740 respectively. The result indicate that the mahkota dewa fruit's (Phaleria macrocarpa) extract possesses hepatoprotetective activity which probably related to its antioxidant activity. Keywords: Phaleria macrocarpa, hepatotoxic

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