Sri Puji Astuti Wahyuningsih, NIDN. 0021026604 and Nadyatul Ilma Indah Savira, NIM. 081624153006 and Win Darmanto, NIDN. 0016066103 (2015) Effect of Polysaccharide Krestin From Coriolus versicolor On Antibody Titer Mice Exposure Due Pseudomonas aeruginosa. In: Proceeding The 6th International Conference on Green Technology. Maulana Malik Ibrahim State Islamic University, Maulana Malik Ibrahim State Islamic University, pp. 412-417. ISBN 2301-4490

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Abstract

The best know commercial polysaccharopeptide preparations of Coriolus versicolor are polysaccharopeptide krestin (PSK). One of the most important functions of PSK is their immunomodulatory actions. The purpose of this study was to analyze the activity of polysaccharides krestin on antibody titer in Mus musculus were exposed toP. aeruginosa. Polysaccharide krestin fractionated and precipitated with 90% ammonium sulphate. Polysaccharide krestin given to the mice strain Balb/C. There were six treatment groups : (K) control , without giving PSK and without exposure to P. aeruginosa, (K +) positive control, giving PSK, (K-) negative control, exposure toP. aeruginosa, (P1) PSK administration before exposure toP. aeruginosa, (P2) PSK administration after exposure toP. aeruginosa, and (P3) PSK administration before and after exposure toP. aeruginosa. Polysaccharide krestin dose was 50 mg/kg bw administered for 7 days via gavage. Exposure toP. aeruginosadone 2 times with an interval of 2 weeks via intraperitoneal. Antibody titer were measured by ELISA. Data were analyzed by descriptive. The results showed that the polysaccharide krestinincreased the antibody titer. Polysaccharides krestin can stimulate the immune response resulting from exposure toP. aeruginosa. Polysaccharideskrestin can be usefulasimmunomodulator. The best know commercial polysaccharopeptide preparations of Coriolus versicolor are polysaccharopeptide krestin (PSK). One of the most important functions of PSK is their immunomodulatory actions. The purpose of this study was to analyze the activity of polysaccharides krestin on antibody titer in Mus musculus were exposed toP. aeruginosa. Polysaccharide krestin fractionated and precipitated with 90% ammonium sulphate. Polysaccharide krestin given to the mice strain Balb/C. There were six treatment groups : (K) control , without giving PSK and without exposure to P. aeruginosa, (K +) positive control, giving PSK, (K-) negative control, exposure toP. aeruginosa, (P1) PSK administration before exposure toP. aeruginosa, (P2) PSK administration after exposure toP. aeruginosa, and (P3) PSK administration before and after exposure toP. aeruginosa. Polysaccharide krestin dose was 50 mg/kg bw administered for 7 days via gavage. Exposure toP. aeruginosadone 2 times with an interval of 2 weeks via intraperitoneal. Antibody titer were measured by ELISA. Data were analyzed by descriptive. The results showed that the polysaccharide krestinincreased the antibody titer. Polysaccharides krestin can stimulate the immune response resulting from exposure toP. aeruginosa. Polysaccharideskrestin can be usefulasimmunomodulator. The best know commercial polysaccharopeptide preparations of Coriolus versicolor are polysaccharopeptide krestin (PSK). One of the most important functions of PSK is their immunomodulatory actions. The purpose of this study was to analyze the activity of polysaccharides krestin on antibody titer in Mus musculus were exposed toP. aeruginosa. Polysaccharide krestin fractionated and precipitated with 90% ammonium sulphate. Polysaccharide krestin given to the mice strain Balb/C. There were six treatment groups : (K) control , without giving PSK and without exposure to P. aeruginosa, (K +) positive control, giving PSK, (K-) negative control, exposure toP. aeruginosa, (P1) PSK administration before exposure toP. aeruginosa, (P2) PSK administration after exposure toP. aeruginosa, and (P3) PSK administration before and after exposure toP. aeruginosa. Polysaccharide krestin dose was 50 mg/kg bw administered for 7 days via gavage. Exposure toP. aeruginosadone 2 times with an interval of 2 weeks via intraperitoneal. Antibody titer were measured by ELISA. Data were analyzed by descriptive. The results showed that the polysaccharide krestinincreased the antibody titer. Polysaccharides krestin can stimulate the immune response resulting from exposure toP. aeruginosa. Polysaccharideskrestin can be usefulasimmunomodulator.

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