Sri Puji Astuti Wahyuningsih, NIDN. 0021026604 (2015) Polysaccharide Krestin Activity from Coriolus versicolor on Antibody Titer of Mice Exposed Staphylococcus aureus. In: Proceeding BaSIC 2016 The 6th Basic Science International Conference. Brawijaya University, Universitas Brawijaya Malang, pp. 241-244. ISBN 2338-0128

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Abstract

(The best know commercial polysaccharopeptide preparations of Coriolus versicolor are polysaccharopeptide krestin (PSK). One of the most important functions of PSK is their immunomodulatory actions. The purpose of this study was to analyze the activity of polysaccharides krestin on antibody titer in Mus musculus exposed to Staphylococcus aureus. Polysaccharide krestin was fractionated and precipitated with 90% ammonium sulphate. Polysaccharide krestin was given on the mice strain Balb/C. There was six treatment groups: (K) control, without adding PSK and without was exposure to S. aureus, (K +) positive control, adding PSK, (K -) negative control, exposure to S. aureus, (P1) adding PSK before exposure to S. aureus, (P2) adding PSK after exposure to S. aureus, and (P3) adding PSK before-after exposure to S. aureus. Polysaccharide krestin dose was 50 mg/kg bw administered for 7 days via gavage. Exposure to S. aureus done 2 times with an interval of 2 weeks via intraperitoneal. Antibody titer were measured by ELISA. Data were analyzed by descriptive. The results showed that the polysaccharide krestin increased the antibody titer on P1. Polysaccharides krestin could stimulate the immune response resulting from exposure to S. aureus. Polysaccharides krestin can be useful as immunomodulator).

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