Iskandar Zulkarnain, 110010412 and Regitta Indira Agusni and Afif Nurul Hidayati, NIDN8855610016 (2019) Comparison of Tea Tree oil 5% Cream, Tea Tree Oil 5%+Permethrin 5% Cream, and Permethrine 5% Cream in Child Scabies. International Journal of Clinical and Experimental Medical Sciences, 4 (6). pp. 87-93. ISSN 2649-8024

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Abstract

Scabies is a common ectoparasit infection caused by a tick of Sarcoptes scabiei var. hominis. The World Health Organization (WHO) categorizes scabies as "Neglected Tropical Diseases" in 2013. Scabies is more common in the tropics, especially child scabies. TTO has been used in communities internationally for over 90 years. TTO is an essential oil derived from leaf distillation and terminal branch of Melaleuca alternifolia plant. TTO has been shown to be effective (in vitro) bactericidal activity, to bacteria such as methicillin-resistant Staphylococcus aureus (MRSA). TTO was used to reduce colonization of MRSA and as an anti-bacterial, anti-fungal, and anti-viral skin infection. TTO is also used as a topical antipruritic drug. The TTO component is described specifically by the International Organization for Standardization Standard (ISO 4720), so the side effects of botanical products can be avoided. An experimental analytical study using randomized clinical trial and double blind parallel design comparing TTO 5% cream (treatment 1), TTO cream 5%+permethrin 5% (treatment 2) with permethrin 5% cream (control) on child scabies. The population of the study were the affected scabies students of junior high school (SMP), age 11-15 years, in 2 Islamic boarding school. Patient were examined on week 0, 1, 2, and 3, in order to decide whether the treatment should be continued or stopped. If complete remission were achieved, treatment was stopped. Examination data were collected and saved in medical records. Statistical analysis were processed using SPSS. At week 1, full recovery occurred in 1 patient (4.2%) in permethrin 5% group, 4 patients (16.7%) in TTO 5% group, and 3 patients (12.5%) in TTO 5%+permethrin 5% group. Chi-square test showed p value = 0.374 which means that there was no significant difference in three groups. At week 2, there were 4 patients (16.7%) in the permethrin 5% group, 13 patients (54.2%) in the TTO 5% group, and 5 patients (20.8%) in the TTO 5%+permethrin 5% group. Chi-square test showed p = 0.008 which means there was significant difference between permethrin 5% group, TTO 5% group, and TTO 5%+permethrin 5% group. We assume that TTO 5% cream is more effective than permethrin 5% cream in child scabies, TTO 5%+permethrin 5% more effective than permethrin 5% cream, TTO 5% cream is more effective than TTO 5%+permethrin 5% in child scabies. There are side effects, irritation in the permethrin 5% group, TTO 5%, and TTO 5%+permethrin 5%, which improved at week 2 of treatment.

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