Emy Koestanti Sabdoningrum,drh., M.Kes., 0010127002 and Sri Chusniati, drh., M.Kes., 0017125703 and Dr. Lilik Maslachah, drh., M.Kes., 0006116105 and Widya Paramita Lokapirnasari (2019) The Potential of Brucella Suis Local Isolates as Vaccine Candidate For Controlling Brucellosis In Indonesia. Prosiding Internasional : Advances in Health Sciences Research (AHSR), volume 5 Proceedings of the 1st International Conference in One Health (ICOH 2017), 5. pp. 322-325. ISSN 978-94-6252-481-1/2468-5739

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Abstract

Brucellosis in pigs is not only causing great economic losses due to a decrease in productivity of livestock but also is zoonotic. Prevention efforts mainly addressed to vaccination and sanitary measures and governance. S19 and RB51 vaccine does not provide protection against infection and abortion in pigs infected with Brucella suis. The purpose of the study was to develop Brucella suis local isolates vaccine as a vaccine candidate against Brucellosis in pigs and then to prevent the spread of brucellosis. The method used laboratory exploration followed by experimental studies using mice. This study used a factorial design. F test analysis used to test the titer of antibodies through CFT methods. The results showed that local isolates attenuated Brucella suis at a concentration of 108 were able to show a good antibody titer 128. This study concluded that Brucella suis local isolates has the ability to protect mice from infection Brucella suis bacteria and has high immunogenicity. Keywords: Brucella suis, Vaccine Candidate, Local isolates

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