EFEKTIVITAS PEMBERIAN LEUCOVORIN TERHADAP KADAR 5-MTHF (5-Methyltetrahydrofolate) SETELAH TERAPI METOTREKSAT DOSIS TINGGI PASIEN ANAK LEUKEMIA LIMFOBLASTIK AKUT (Penelitian dilaksanakan di Divisi Hematologi-Onkologi SMF Ilmu Kesehatan Anak RSUD Dr. Soetomo Surabaya)

YUFITA RATNASARI WILIANTO, 051715153020 (2019) EFEKTIVITAS PEMBERIAN LEUCOVORIN TERHADAP KADAR 5-MTHF (5-Methyltetrahydrofolate) SETELAH TERAPI METOTREKSAT DOSIS TINGGI PASIEN ANAK LEUKEMIA LIMFOBLASTIK AKUT (Penelitian dilaksanakan di Divisi Hematologi-Onkologi SMF Ilmu Kesehatan Anak RSUD Dr. Soetomo Surabaya). Thesis thesis, Universitas Airlangga.

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Abstract

One of the cytotoxicity of high-dose methotrexate is the occurrence of 5-MTHF depletion in the body. Leucovorin can be used to selectively “rescue” cells from the adverse effects of methotrexate. Leucovorin supplies the necessary cofactor blocked by methotrexate, enters the cells via the same active transport system as methotrexate.

Item Type: Thesis (Thesis)
Additional Information: KKB KK TFK 25/19 Wil e
Uncontrolled Keywords: Acute Lymphoblastic Leukemia (ALL), Leucovorin, 5-MTHF (5- Methyltetrahydrofolate), High-Dose Methotrexate (HD-MTX).
Subjects: R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica
Divisions: 05. Fakultas Farmasi > Farmasi Klinis
Creators:
CreatorsNIM
YUFITA RATNASARI WILIANTO, 051715153020UNSPECIFIED
Contributors:
ContributionNameNIDN / NIDK
Thesis advisoryulistiani, '0028046605UNSPECIFIED
Depositing User: Unnamed user with email indah.fatma@staf.unair.ac.id
Date Deposited: 11 Oct 2019 08:28
Last Modified: 11 Oct 2019 08:28
URI: http://repository.unair.ac.id/id/eprint/88919
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