KARINA CITRA RANI, 050710022 (2012) PENGARUH TWEEN 80 DALAM DISPERSI PADAT ALOPURINOL-PEG 8000 (5:5) TERHADAP LAJU DISOLUSI ALOPURINOL. Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

Alopurinol is a commonly used drug in the treatment of chronic gout or hyperuricemia. Alopurinol is practically insoluble in water, but it has good penetration on the biological membrane, so that dissolution rate is the rate limiting step of drug absorption process and determine the bioavability of drug after oral administration. Solid dispersion could enhance dissolution rate of alopurinol. PEG 8000 is one of matrix that usually used in solid dispersion. Combination between PEG 8000 as matrix and Tween 80 as surfactant could enhance dissolution rate of alopurinol. The aim of this study was to enhance the dissolution rate of alopurinol by preparing ternary solid dispersion using PEG 8000 and Tween 80. Solid dispersion system could increase drug wettability, decrease the particle size of drugs, decrease surface tension between drug and dissolution medium so that the dissolution rate of alopurinol could increase. Solid dispersion system of alopurinol-PEG 8000-Tween 80 were made by combination technique, solvent evaporation-melting method with ratio of 5:5:1 and 5:5:2. Evaluation were carried out by dissolution test of solid dispersion of alopurinol-PEG 8000-Tween 80, physical mixtures and alopurinol substance. Solid dispersion characterized by powder X-ray diffraction. Investigations of the properties of the solid dispersions were performed using powder X-ray diffraction (PXRD). The result showed that solid dispersion of alopurinol-PEG 8000-Tween 80 5:5:2 give the highest dissolution rate compare to the physical mixture and alopurinol substance. Afterwards, the results from PXRD studies showed the decreased intensities in diffraction peaks of alopurinol in solid dispersions.

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