SETIAJI ARIF TRI WIDAGDA, 050710158 (2012) PENGARUH POLOXAMER 188 DALAM DISPERSI PADAT ALOPURINOL-PEG 8000 TERHADAP LAJU DISOLUSI ALOPURINOL. Thesis thesis, UNIVERSITAS AIRLANGGA.

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Abstract

Alopurinol is a commonly used drug in the treatment of chronic gout or hyperuricemia. Alopurinol is a drug which practically insoluble in water, but it has good penetration on the biological membrane, so its dissolution rate is the rate limiting step of drug absorption process and determine bioavability of oral drug administration. Solid dispersion could enhance dissolution rate of alopurinol. PEG 8000 is one kind of matrix that usually used in solid dispersion. Combination between PEG 8000 as matrix and poloxamer 188 as surfactant could enhance dissolution rate of alopurinol. The aim of this study was to enhance dissolution rate of alopurinol preparing into solid dispersion of PEG 8000 with the addition of poloxamer 188 could increase drug wettability, decrease surface tension between drug and dissolution medium so that the dissolution rate of alopurinol could increase. Solid dispersion system of alopurinol-PEG 8000-poloxamer 188 were prepared by solvent evaporation-melting method with ratio of 5:5:1 and 5:5:2. Evaluation were carried out by dissolution test of solid dispersion of alopurinol-PEG 8000-poloxamer 188, physical mixtures and alopurinol substance. Solid dispersion characterized by powder X-ray diffraction. Investigations of the properties of the solid dispersions were performed using powder X-ray diffraction (PXRD).The result showed that solid dispersion of alopurinol-PEG 8000-poloxamer 188 (5:5:2) give the highest dissolution rate compare to the physical mixtures and alopurinol substance. Afterwards, the results from PXRD studies showed the decreased intensities in diffraction peaks of alopurinol in solid dispersions.

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