ESTI ROSSA LARASATI, 051511133003 (2019) PENGARUH KOMBINASI POLIMER DALAM PATCH TIPE MATRIKS TERHADAP EFEKTIVITAS ANTIINFLAMASI MELOKSIKAM (Kombinasi Polimer : Natrium Alginat, Hidroksi Propil Metil Selulosa E15, Etil Selulosa N22). Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

Meloxicam is an NSAID drug that can cause gastric irritation in oral administration. Transdermal drug delivery system as matrix type-patch can avoid its side effect. This study aimed to determine the effect of hydrophilic and hydrophobic polymer combinations to anti-inflammatory effect of matrix type-meloxicam patch. Two formulations of meloxicam patches were composed of sodium alginate, hydroxyl propyl methyl cellulose E15 (HPMC E15) and ethyl cellulose N22 (EC N22) in ratios of 4.5: 5: 1.5 as a formula 1 and 5: 4.5: 1.5 as formula 2. The matrix type-transdermal patch of meloxicam was prepared by mixing all dispersion polymers matrix and meloxicam. The matrix type-transdermal patch was evaluated for organoleptic properties, weight variation, moisture content, flatness, the surface morphology of matrix type-transdermal patch, drug content and homogeneity. All independent variables had no significant effect on the dependent variables (p-values > 0.05) using independent Sample T-test except the moisture content. The rat paw edema test was performed to evaluate the anti-inflammatory effect of matrix type-transdermal meloxicam patch. Thus, formula 1 had provided more effective anti-inflammatory effect than formula 2.

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