RISQY SOBRIYA ANGGRYNI, 051511133034 (2019) PENGARUH SISTEM DISPERSI PADATANDROGRAFOLIDA-KITOSAN TERHADAP AKTIVITAS ANTI MALARIA SECARA IN VIVO PADA MENCIT TERINFEKSI Plasmodium berghei. Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

Andrographolide (ADG) is a diterpene lactone derived from the herb Sambiloto (Andrographis paniculate) which have some of pharmacological effects. Its poorly soluble in water causes limited absorption and bioavailability. Solid dispersion systems can be used to increase the solubility and dissolution rate of medical substances with low water solubility. Solid dispersion systems of andrographolide-chitosan (SDS ADGCTS) is prepared by the solubilization-spray drying method. The purpose of this study was to determine the effect of andrographolide-chitosan solid dispersion system on the antimalarial activity in Plasmodium berghei infected mice. Characterization of andrographolide-chitosan solid dispersion system using SEM showed the shape of spherical, DTA showed decrease endothermic peak and a lower melting point in the solid dispersion system, and X-ray difactogram showed a decrease in the intensity of the diffraction showing the crystallinity of andrographolide. In vivo antimalarial test was done using Peter’s 4 days suppressive test. The result showed the in vivo antimalarial activity of andrographolide-chitosan solid dispersion systems increase inhibition of andrographolide against Plasmodium berghei mice infected. Its average percentage inhibition at fifth day is 54,71± 2,14% and increased by 1,56 times if compared with andrographolide.

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