Antioxidant and cytotoxic agent from the rhizomes of Kaempferia pandurata Repository

Antioxidant and cytotoxic agent from the rhizomes of Kaempferia pandurata

Mulyadi Tanjung and Tjitjik Srie Tjahjandarie and Mulya Hadi Sentosa (2013) Antioxidant and cytotoxic agent from the rhizomes of Kaempferia pandurata. Asian Pacific Journal of Tropical Disease, 3 (4). pp. 401-404. ISSN 2222-1808

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Official URL: https://www.sciencedirect.com/science/article/pii/...

Abstract

Objective:To determine antioxidant and cytotoxic activity of two flavanones, pinocembrin (1) and pinostrobin (2) from the rhizomes of Kaempferia pandurata. The chemical structures of both compounds were determined based on spectroscopic data, including UV, IR, MS and NMR spectra. Methods:The antioxidant activities of pinocembrin (1) and pinostrobin (2) were assayed by using 2,2-diphenyl-1-picrylhydrazyl. Cytotoxic assay was done by using brine shrimp lethality test,and cytotoxic properties was tested against murine leukemia P-388 cells. Results:Compounds 1-2 were evaluated for their antioxidant properties against DPPH, showingtheirIC50 were 5 816 and 6 268µ mol/L; brine shrimp lethality test: LC 50 23.3 and 60.5 µ g/mL; murine leukemia P-388: IC 50 176.3 and 218.5 µ mol/L. Conclutions:The results indicated that pinocembrin (1) was slightly more active than pinostrobin (2).

Item Type:

Article

Uncontrolled Keywords:

Flavanone, Pinocembrin, Pinostrobin, Kaempferia pandurata, Antioxidant, Cytotoxic

Subjects:

Q Science > Q Science (General)
Q Science > QD Chemistry

Divisions:

08. Fakultas Sains dan Teknologi > Kimia

Creators: