FIRZA MUNIF LAHDJI, 050810043 (2012) PENGARUH ETILSELULOSA 10 CPS TERHADAP MUTU FISIK DAN KARAKTERISTIK FLOATING TABLET RANITIDIN HCL DENGAN HPMC K15M. Skripsi thesis, UNIVERSITAS AIRLANGGA.

Preview	Text (ABSTRACT) gdlhub-gdl-s1-2013-lahdjifirz-22854-7.abst-t.pdf Download (115kB) | Preview
	Text (FULLTEXT) FIRZA MUNIF LAHDJI-min.pdf Restricted to Registered users only Download (1MB) | Request a copy

Abstract

The rationale of this research was to prepare a gastro retentive drug delivery system of Ranitidine HCl. Floating Drug delivery system used to target drug release in the stomach or the upper part of intestine. Currently, floating tablets are one of the important categories of drug delivery systems with gastric retentive behavior. Ranitidine HCl is a H2 blocker and metabolized in the colon that can degrade the drug, leading to a low bioavailability. Hence there is need to develop a dosage form that release the drug in stomach so that it can be absorbed from upper part of gastrointestinal track leading to improved bioavailability. Four different formulas of ranitidine HCl were prepared by wet granulation method using hydroxypropyl methylcellulose K15M 20% and different concentration of ethylcellulose 10 cps, which first formula (FI) without ethylcellulose 10 cps. The FII, FIII, and FIV used ethylcellulose 10 cps 5%, 10% and 15% respectively. The prepared tablets were evaluated on their physical and floating characteristics. The results showed that the physical characteristic is improving as the increasing concentration of ethylcellulose 10 cps and there is no difference for the floating characteristic between each formula. Entirely the formula floats less than 30 seconds for more than eight hours

Actions (login required)

View Item