DESY KURNIAWATI, 050810139 (2012) PENGARUH PERBANDINGAN HPMC K4M DAN HPMC K100M TERHADAP KARAKTERISTIK FLOATING DAN PELEPASAN RANITIDIN HCL DARI TABLET FLOATING. Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

The rationale of this research was to prepare a gastroretentive drug delivery system of Ranitidine HCl. Floating Drug delivery system used to target drug release in the stomach or to the upper part of the intestine. Currently, floating tablets are one of the important catagories of drug delivery systems with gastric retentive behavior. Ranitidine is a H2 blocker, absorbed from the upper part of gastrointestinal track, and metabolized in the colon that can degrade the drug, leading to a low bioavailability. Hence there is need to develop a dosage form that release the drug in stomach so that it can be absorbed from upper part of gastrointestinal track leading to improved bioavailability. Four different formulas of ranitidine HCl were prepared by wet granulation method using 20% of hydroxypropyl methylcellulose (HPMC) K4M and HPMC K100M. The ratio of hydroxypropyl methylcellulose K4M and hydroxypropyl methylcellulose K100M in F1, F2, F3, and F4 is 1:0, 1:2, 1:4, 1:6 respectively. The prepared tablets were evaluated on their floating and drug release characteristics. The dissolution test was performed using 900 ml of 0,1 N hydrochloric acid, at 37 ± 0,5°C and 50 rpm. The result showed that the Floating lag time, it is a floating characteristic is improving as the increasing concentration of HPMC K100M in formula’s ratio. The kinetic release of all formulas followed both first order and Higuchi’s model and the release mechanism dominated by non-fick diffusion.

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