TIKA APRIANA MARZA, 051511133044 (2019) PENGARUH STERILISASI ULANG TERHADAP KADAR LIDOKAIN DI RSUD DR.SOETOMO. Skripsi thesis, Universitas Airlangga.

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Abstract

Lidocaine is an acanilide derivative that works as a local anesthetic. Patients undergoing surgery has high risk of infection, therefore it is very important to note that the outside part of lidocaine hydrochloride ampoule is sterile so that it does not become a contaminant by sterilization using autoclave at 121°C for 15 minutes. The possibility of a decrease in lidocaine hidrochloride content due to the re-sterilization process causes this research to be necessary. This research was carried out under optimal and validated conditions using the High Performance Liquid Chromatography (HPLC) system the octadesilsilan (C18) as stationary phase, and acetonitrile: glacial acetic acid buffer pH 3,4 (75:25, v/v) as mobile phase, flow rate of 1.0 ml / minute, temperature of column 30oC, with a UV detector at a wavelength of 254 nm. The sample used in this study was mixture of lidocaine hydrochloride in dextrose. The consentration of lidocaine hydrochloride for injection “x” brand before re-sterilization have a range from 5.04-5.19%, and after re-sterilization the concentration have a range from 4.93-5,06%. There was a decrease in lidocaine hydrochloride consentration after resterilization, but it was not significant because the levels of lidocaine hydrochloride obtained were as stated on the packaging label in the required range of Indonesian Pharmacopoeia Edition V.

Item Type:	Thesis (Skripsi)
Additional Information:	KKB KK-2 FF.FK 49/19 Mar
Uncontrolled Keywords:	re-sterilization, autoclave, anesthesia, epidural, lidocaine hydrochloride, dextrose, HPLC, assay.
Subjects:	R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica
Divisions:	05. Fakultas Farmasi > Farmasi Klinis
Creators:	Creators NIM TIKA APRIANA MARZA, 051511133044 UNSPECIFIED
Contributors:	Contribution Name NIDN / NIDK Thesis advisor Dra. Toetik Aryani, M.Si., Apt, NIDN :'0011046107 UNSPECIFIED
Depositing User:	Dwi Marina
Date Deposited:	19 Nov 2019 01:25
Last Modified:	19 Nov 2019 01:25
URI:	http://repository.unair.ac.id/id/eprint/91159
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