KRISTIN DIANA NINGRUM, 050810174 (2012) PENGARUH KONSENTRASI LARUTAN CHITOSAN 19 cPs TERHADAP KARAKTERISTIK FISIK DAN PROFIL PELEPASAN MIKROPARTIKEL KETOPROFEN-CHITOSAN (dibuat dengan metode spray drying pada suhu inlet 100oC). Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

Microparticles is particles that have size between 1-1000 μm. The aim of this research was to investigate the effect of chitosan concentration (F1 = 0,125%, F2 = 0,25%, and F3 = 0,5%) on physical characteristic and drug release of microparticles ketoprofen-chitosan. Microparticle was prepared by ionic gelation using sodium tripolyphosphate as cross linker, then dried by spray drying method. The result showed that microparticles have spherical shape and as the chitosan concentration increased, the mean particle size microparticles increased. The result also showed that as the increased of chitosan concentration, the entrapment efficiency of the drugs increased. In simulated intestinal fluid, the release ketoprofen of F1, F2, and F3 was slower than ketoprofen control, which could be seen by the slope. F1, F2, F3, and control each has slope as 10,1791 ± 0,7127 (%/minute1/2), 10,3641 ± 0,0678 (%/minute1/2), 10,1151 ± 1,0778 (%/minute1/2), dan 12,83021 ± 0,2410 (%/minute1/2).

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