Haninda Iffatuz Zahrah and Theresia Indah Budhy S. and Edhi Jularso (2015) Potensi ekstrak etanol kulit batang kayu tengkawang pelepak (shorea seminis) terhadap apoptosis sel kanker rongga mulut pada mencit mus musculus yang diinduksi benzo(a)pyrene. Oral and Maxillofacial Pathology, 2 (2). pp. 1-6.

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	Text (PEER REVIEW) Validasi dan Kelaikan Etik (Potensi Ekstrak Etanol).pdf Download (691kB)

Abstract

Background: Oral cancer is a serious problem in some countries. This cancer on the 6th grade from all of the cancer in the world. Nowadays, therapy of oral cancer are surgery and chemotherapy that has a lot of side effects. A therapy using ethanol extract from stem bark of Shorea seminis that is minimum side effects yet easy to be found. Shorea seminis containing oligostilbenoids compound, this compound can increas p53 gene expression. Purpose: To prove and analyze the best dose of ethanol extract from stem bark of Shorea seminis to increas apoptosis of oral cancer. Methods: This research is preliminary research and the laboratories experimental with post test only control group design. There are 26 Mus musculus mice as research samples, and divided into four group, namely KK (control group), KP1 (250 mg/kg BB), KP2 (500 mg/kg BB), and KP3(750 mg/kg BB). All of this samples were injected by benzo(a)pyrene intra muscular in oral twice a week for a month with the dose 8 mg/kg BB. Furthermore, each group was given stem bark of Shorea seminis ethanol extract everyday with the dose 250 mg/kg BB, 500 mg/kg BB, and 750 mg/kg BB for a month. All samples were sacrificed and processing to detect apoptosis by immunohistochemistry among group. The data were tabulated and analyze statistically. Result: The total of apoptosis in KP3 is higher than KP1 and KP2. This result prove that stem bark of Shorea seminis ethanol extract can increase apoptosis of oral cancer cell. The dose 750 mg/kg BB has the hinghest total of apoptosis compared with another dose. Conclusion: Stem bark of Shorea seminis ethanol extract can increas apoptosis of oral cancer cell, expecially in dose of 750 mg/kg BB.

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