Muhammad Miftahussurur and Yoshio Yamaoka and David Y. Graham (2016) Helicobacter pylori vacuolating cytotoxin and gastric cancer risk: reconsidered. Translational Cancer Research, 5 (3). pp. 1-6. ISSN 22196803

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Abstract

Although Helicobacter pylori (H. pylori) cause gastric cancer, cancer develops in a fraction of H. pylori infected patients. Based on the notion that polymorphisms in the H. pylori vacuolating cytotoxin gene might be a determinant of clinical outcome, Abdi et al. used meta-analysis to examine the association between vacA gene subtypes and the risk of developing atrophic gastritis, intestinal metaplasia or gastric cancer. H. pylori infection causes gastric mucosal inflammation which underlies the development of peptic ulcer disease and gastric cancer (2). The outcome of any H. pylori infection reflects complex interactions between the host, the bacterium and the environment. These interactions are evident clinically as marked geographic variation in the prevalence of H. pylori-related diseases.

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