Arvi Dian Prasetia Nurwidda and Poernomo Boedi Setiawan and Iswan Abbas Nusi and Herry Purbayu and Titong Sugihartono and Ummi Maimunah and Ulfa Kholili and Budi Widodo and Amie Vidyani and Muhammad Miftahussurur and Husin Thamrin (2017) Thrombocytopenia in Chronic Hepatitis C. In: Proceedings of The Surabaya International Physiology Seminar. SCITEPREES-Science and Technology Publications, Lda., Surabaya, pp. 446-452. ISBN 978-989-758-340-7

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Abstract

Hepatitis C is a disease caused by hepatitis C virus (HCV), which can cause liver cirrhosis and cancer. Chronic hepatitis C infection has extrahepatic manifestations, including thrombocytopenia. Patients with this disease have exhibited varied thrombocytopenia prevalence, with reported prevalence of more than 24%. Thrombocytopenia pathogenesis in chronic hepatitis C infection involves the interaction of various factors, including liver fibrosis, hypersplenism, bone marrow suppression, immune dysfunction and decreased levels and activity of thrombopoietin. Thrombocytopenia affects chronic hepatitis C infection treatment, including adjustment of antiviral dose especially Peg-IFN, delayed or canceled invasive procedures for diagnosis and therapy related to surgery. Thrombocytopenia therapy in patients with chronic hepatitis C can be divided into two: pharmacological treatments, including steroid administration, platelet transfusion, targeted thrombopoiesis therapy, thrombopoietin recepto r activation therapy, and non-pharmacological therapy, including splenectomy and partial splenic embolization. Steroid administration for thrombocytopenia treatment in chronic hepatitis C infection is not used because it can worsen liver damage. Some pharmacological therapies still require further research and are still in the experimental stage in regard to their effectiveness and safety in thrombocytopenia treatment in chronic hepatitis C infection.

Item Type:	Book Section
Uncontrolled Keywords:	Chronic hepatitis C, peg-IFN, steroid, thrombocytopenia, HCV
Subjects:	R Medicine > R Medicine (General) R Medicine > RC Internal medicine
Divisions:	01. Fakultas Kedokteran > Ilmu Penyakit Dalam
Creators:	Creators NIM Arvi Dian Prasetia Nurwidda UNSPECIFIED Poernomo Boedi Setiawan NIDN8886900016 Iswan Abbas Nusi NIDN0028025003 Herry Purbayu NIDN8884800016 Titong Sugihartono NIDN8836800016 Ummi Maimunah NIDN8896900016 Ulfa Kholili NIDN0004047511 Budi Widodo NIDN8804800016 Amie Vidyani NIDN0028018002 Muhammad Miftahussurur NIDN0029097909 Husin Thamrin NIDN8825800016
Depositing User:	arys fk
Date Deposited:	06 Dec 2019 02:37
Last Modified:	06 Dec 2019 02:37
URI:	http://repository.unair.ac.id/id/eprint/91969
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