Dwi Setyawan and Bambang Widjaja and Retno Sari (2013) Study on Crystallinity and Compactibility of Binary Mixture of Analgesic Subtances with Microcrystalline Cellulose. International Journal of Pharmacy and Pharmaceutical Sciences, 5 (3). pp. 784-789. ISSN 0975-1491

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Abstract

Objectives: The aim of this study was to investigate crystallinity and compatibility transformation of two binary mixtures of analgesic substance with excipient due to mixing and compression. Methods: Analgesic substances used in this study were mefenamic acid (MA) and acetaminophen (AC). Each substance was mixed with microcrystalline selolusa as excipient with drug-excipient ratio of 70:30, 80:20 and 90:10 %w/w then compressed with pressure of 29.4 kN. Characterization was done by Powder X-Ray Diffraction (PXRD), thermal analysis (DTA), FTIR spectrometer and a Scanning Electron Microscope (SEM). Mechanical properties was also evaluated by calculating its tensile strength Results: Evaluation of crystallites size of MA and MA-MCC mixture showed that the value of MA crystallite size is relatively fixed in all the peaks observed. Crystallite size of the AC and AC-MCC mixture also showed similar results with MA. From the elastic modulus curve, it was recognized that the tensile strength of MA is greater than AC, it indicates that the MA is more plastic than AC. Conclution: X-ray powder diffraction of binary mixture indicated that intensity of both MA and AC decreased with increasing amount of MCC. The average crystallite size were 15-19 Å (MA) and 21-30 Å (AC). It was known that MA has compactibility better than AC.

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