KHOIRUN NISA, 050710302 (2011) KARAKTERISASI SISTEM MIKROEMULSI TIPE W/O DENGAN BAHAN OBAT NATRIUM DIKLOFENAK (Perbandingan Konsentrasi Surfaktan (Span 80-Tween 80) dan Kosurfaktan (Etanol 96%) 5:1 , 6:1, dan 7:1). Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

The aim of the present study was to ma ke comparison of characteristic of diclofenac sodium (DS) from microemulsi on (M) vehicles containing soybean oil, nonionic surfactants (Span 80 and Tween 80), and ethanol 96% as co-surfactant. The optimum surfactant : cosurfact ant (S:CoS) weight ratios and microemulsion areas were defined by phase diagrams approach. Three microemulsion formulations (5:1, 6:1 and 7:1) were created, and their physic ochemical properties were examined for the organoleptics, conductivit y, size measurement and di stribution by dynamic light scattering, also the soluble cap acity of sodium diclofenac. According to organoleptic evaluation seems all formulas has clear ye llow color and visc ous consistency. The conductivity results showed that DS-loade d microemulsions have higher conductivity values (0.64-0.80 μs) than unloaded formul ations (0.04-0.11 μs). Based on analysis of varians (ANOVA) test, the soluble capacity of all formula doesn’t have a significant differentiation. From the size measurement evaluation, formula 6:1, which has droplet size about 339,1 nm, was shown as the best formula than the others. In conclusion, microemulsion 6:1 may be a more appropriate formulation than the other two formulations studied.

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