GANES MAHARDHIKA, 050710063 (2011) KARAKTERISASI SEDIAAN DAN UJI PENETRASI NATRIUM DIKLOFENAK DENGAN SISTEM MIKROEMULSI W/O DALAM BASIS GEL CARBOMER 940 (Mikroemulsi W/O dengan Surfaktan Span 80-Tween 80 : Kosurfaktan Etanol 96% = 6:1). Skripsi thesis, UNIVERSITAS AIRLANGGA.
|
Text (ABSTRACT)
gdlhub-gdl-s1-2012-mahardhika-22423-ff3251-k.pdf Download (383kB) | Preview |
|
![[img]](https://repository.unair.ac.id/style/images/fileicons/text.png) |
Text (FULLTEXT)
gdlhub-gdl-s1-2012-mahardhika-18744-ff3251-k-min.pdf Restricted to Registered users only Download (2MB) | Request a copy |
Abstract
The aim of this study is to observe charac terization dosage form and penetration of diclofenac sodium with microemulsion w/o sy stem which contained ratio surfactant Span 80 – Tween 80 and cosurfactant ethanol 96% = 6:1 in Carbopol 940 gel base through Wistar rat skin membrane. Diclofenac sodium gel with emulsion system was used as control. The evaluation included characte ristics of dosage form (organoleptis, pH, spreadability) and penetration test. Data from pH test, spea dability, and spread diameter of zero load, were evaluated based on independent sample t test According to the characteristic evaluation fr om each formula, microemulsion system in gel base (formula I) showed thicker consis tency than emulsion system in gel base (formula II). Different system gave no effect on pH but it gave effect on speadability and spread diameter of zero load. Data analyi s showed that pH of formula I was 6,00±0,02 and formula II was 5,97±0,03. Spreadabil ity of formula I was 0,0120 ± 0,0020 cm and formula II was 0,0480 ± 0,0100 cm. Spread diameter of zero load for formula I was 4,97±0,50 cm and formula II was 11,30±1,05 cm. Di ssolution test was carried out with apparatus 5-paddle overdisk in phos phate buffer 7,4 ± 0,05, temperature 37 o C, 100 rpm . The result of diclofenac sodium penetration test were flux and membrane permeability. The rate of flux in formula I (0,679±0,116 μ g/cm 2 /min) and formula II (0,830±0,217 μ g/cm 2 /min) while the rate of permeability membrane in formula I ( 6,5006 ± 1,1064 cm/min) and formula II (8,0022 ± 2,0916 cm/min). It was analyzed by statistic programmed of SPSS using independent sample t-test with degree of confident 95% ( α =0,05). The result showed that there wa s no significant difference between each formula
| Item Type: | Thesis (Skripsi) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Additional Information: | KKB KK-2 FF 325 11 Mah k | |||||||||
| Uncontrolled Keywords: | DIELOFENAC | |||||||||
| Subjects: | R Medicine > RS Pharmacy and materia medica | |||||||||
| Divisions: | 05. Fakultas Farmasi > Farmastika | |||||||||
| Creators: |
|
|||||||||
| Contributors: |
|
|||||||||
| Depositing User: | Dwi Marina | |||||||||
| Date Deposited: | 27 Jan 2012 12:00 | |||||||||
| Last Modified: | 06 Jul 2017 18:01 | |||||||||
| URI: | http://repository.unair.ac.id/id/eprint/9607 | |||||||||
| Sosial Share: | ||||||||||
Actions (login required)
 |
View Item |