DIAN ARFITASARI, 050911132 (2013) UJI PELEPASAN ASAM P-METOKSISINAMAT SISTEM SOLID LIPID NANOPARTIKEL DENGAN KOMBINASI LIPID BEESWAX DAN GLISERIL MONOSTEARAT. Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

The research objective is to investigate the effect of lipids combination of beeswax and glyceryl monostearate formed in SLN on the release of p-methoxycinnamic acid. Drug release measured with apparatus-5-paddle overdisk in phosphate buffer 7,4 ± 0,05, temperature 32oC, 100 rpm, with diffusion cells using celophan membrane within 11 hours. The drug release rate named flux, calculated from slope of linear regression between √t versus the cumulative amount of released pmethoxycinnamic acid on steady state. Flux of p-methoxycinnamic acid SLN with beeswax, glyceryl monostearate combination, and SLN with glyceryl monostearate were 121,82 ± 2,7046 μg/cm2/min1/2, 103,4817 ± 6,7831 μg/cm2/min1/2 and 100,8933 ± 4,9545 μg/cm2/min1/2. Flux was also evaluated using one way ANOVA statistical test continued with HSD test. Research result shows the effect of lipids combination of beeswax and glyceryl monostearate formed in SLN on the release of p-methoxycinnamic acid formed decreased compared with SLN with beeswax but there were no difference compared with SLN with glyceryl monostearate.

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