Siprianus Ugroseno Yudho Bintoro and Agung Prasetiy and Ami Ashariati Prayoga (2018) Association between modified wells score and D-dimer in malignant lymphoma patients. Journal of Molecular Oncology Research, 2 (2). pp. 21-26. ISSN 2614-1264

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Abstract

Background: Cancer patients have a high risk of new or recurrent venous thromboembolism. Thrombosis decrease 1 year life expectancy of malignant lymphoma patients. In the last 10 years, it has been continuosly developed a method to detect early venous thrombosis by combining Modified Wells (MW), D-dimer and Doppler ultrasonography level but only 25% are detected early. Objective: We analyzed the association between MW score and D-dimer level. Method: It is an analytic observational study of LNH and LH patients based on clinical and histopathological diagnosis who had never received chemotherapy. The subjects were 35 patients with malignant lymphoma consisting of 30 LNH patients and 5 LH patients. D-dimer was measured using immunochromatography method. Result: There was a positive linear relationship between MW score and D-dimer level with p=0.001 and r=0.462. However, there was no association in LH patients (p=0.215). Conclusion: There was a moderate positive correlation between MW scores and D-dimer levels in naive LNH patients.

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