Purwati, Purwati (2019) Metabolite Stem Cell for Skin Rejuvenation. In: Journal of Tissue Science and Engineering. 12th Annual Conference on Stem Cell and Regenerative Medicine, 10 . Hilaris Publisher, Helsinki. ISBN 2157-7552

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Abstract

Skin aging is natural process where renewal of skin cells and collagen production slows down, as well as the weakening of internal support structure and natural protective layer of skin. Several anti-aging therapies are widely used in dealing with aging. Stem cell metabolites are rich in growth factors such as cytokines IL-10, IL-4, EGF, GM-CSF and TGF-β. These cytokines can penetrate skin layer to stimulate the growth of new cells and increase nutrition, accelerate skin metabolism to inhibit premature aging, stimulate skin to produce new proteins, collagen and elastic fibers, also reduce black pigments. Previous research focuses on in vitro and animal study of stem cell metabolites derived from placenta for skin regeneration. This study is an advanced stage by focusing on clinical trial in 30 patients who met the inclusion and exclusion criteria to be applied with stem cell metabolites on their face. Subjects were examined their face conditions by using janus skin analyzer to see markers on their skin and applied stem cell metabolites in their face twice per day, at day and night with single-use doses of three pumping. Evaluation was carried out before and after application of stem cell metabolites using janus in six weeks. The results of janus examination evaluated were spot, pore, roughness, wrinkle, UV acne, UV spot and UV moisture. The percentage of spot, pore, roughness, wrinkle, UV acne and UV spots are decreased, while the percentage of UV moisture is increased in almost all subjects who were evaluated for six weeks. In qualitative, almost 90% subjects are satisfied with the results of the application of stem cell metabolites. The subjects felt that facial wrinkles were reduced, the face was smoother and supple and pigmentation was reduced. It can be concluded that stem cell metabolites formula are effective and efficient in skin regeneration.

Item Type:	Book Section
Additional Information:	12th Annual Conference on Stem Cell and Regenerative Medicine
Uncontrolled Keywords:	METABOLISM; SKIN CARE
Subjects:	Q Science R Medicine
Divisions:	15. Fakultas Vokasi > Departemen Kesehatan
Creators:	Creators NIM Purwati, Purwati NIDN0025027203
Depositing User:	Tn Khamim Sahid
Date Deposited:	01 Sep 2020 05:48
Last Modified:	21 Oct 2022 09:07
URI:	http://repository.unair.ac.id/id/eprint/96306
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