CHARLES NURSALIM, 050911175 (2013) PREPARASI NANOPARTIKEL KITOSAN DENGAN MANITOL SEBAGAI KRIOPROTEKTAN (dengan Metode Gelasi Ionik dan Pengeringan Beku). Skripsi thesis, UNIVERSITAS AIRLANGGA.
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Abstract
The aim of this research was to investigate the effect centrifugation, freezing step, and manitol as cryoprotectant on chitosan nanoparticles prepared by ionic gelation then freeze dried. Chitosan nanoparticles that form by ionic gelation method was separated by centrifugation process from its solvent. In this research, the effect of speed and time of centrifugation, freezing temperature and freezing time, and cryoprotectant amount were studied. The result showed that nanoparticles chitosan with mannitol 10% w/v indicated had spherical shape after being centrifuged at 4000 rpm for 5 minutes and freezed at -30oC with 3,5 mbar vacum press for 1 hour. Otherwise, SEM image of dried nanoparticles showed that agregation formed after drying for 24 hours.
| Item Type: | Thesis (Skripsi) | ||||||
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| Additional Information: | KKB KK-2 FF F 83/13 Nur p | ||||||
| Uncontrolled Keywords: | nanoparticles, chitosan | ||||||
| Subjects: | R Medicine > RS Pharmacy and materia medica | ||||||
| Divisions: | 05. Fakultas Farmasi > Farmastika | ||||||
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| Depositing User: | Dwi Marina | ||||||
| Date Deposited: | 08 Jan 2014 12:00 | ||||||
| Last Modified: | 28 Jul 2016 09:00 | ||||||
| URI: | http://repository.unair.ac.id/id/eprint/9646 | ||||||
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